Reseach & Development

『Establishment of quality 』

We always access to new synthesis technology, analysis technology, pharmaceutical affairs regulation, and we are working to research and development for "More better drug substance" to send to everyone. Based on accumulated organic synthesis system, search the most suitable synthesis root which is most suitable for industrialization and from design the goal product quality profile, our development of "More better drug substance" will start. Of course chemical properties, physical properties, cost, safety supply, the safe operation, provide information, delivery, speed are important, and having communication with custmer is improtant element for quality design. Our mission is to have a communicate and include required quality.

We promise the total support, the development of the GE and consignment pharmaceuticals.

Our R&D dept, has 3 groups which are "Process development G", "Development technology G", and "Analysis development G", and we use each technology and we create the process and products which ingratiate the customer's needs that "More better quality", "More safety" and "Cost reduction".

＜Initial stage＞
　Of course importance the speed and secure delivery, we suggest the improvement of based on development technology, new synthesis root and process, also suggest the 　　 problem of existing process. And we discuss about include the quality order of customer into which process.
　■We work on development with the top priority in quality and deliverry, and brush up the development process, and suggest the safe development process.
　■We create the necessary analysis method for the development process which suggested, and include the customer's quality needs which from initial stages of development.

＜Middle stage　to　Final stage　and　Productization＞
　■From the laboratory and the trial data which were provided early in development, use the accumulated scale-up technology to guarantee the secure scale-up and process 　　validation.
　■For perform a reliable commercial production,we work together each sections, with efficient equipments and appropriate pharmaceutical affairs corresponding.

　『　Maintenance of quality　』
　　We can build and share the development environment using all our resources.
　　「Quality Assurance Department」,「Manufacturing department」,「Sales department」,and more.

Reaction examples

　Example-１：Hammick reaction　▼　

　Example-２：Catalytic alkylation_Grignard reagent,homogenous　▼　

　Example-３：Borane reduction　▼　

　Example-４：Lithiation　▼　

　Example-５：Heterogeneity catalyst_Raney nickel　▼　

　Example-６：Cyanation　▼　

　Example-７：Alkylation_Sodium amide 　▼　

　Example-８：Oxidation_Sulfide　▼　

Our technology

Since 1947,We are continuing the development of the technology.

■Extreme low temperature reactions

＜Manufacturing facility_example＞

Brine indirect cooling system
　　『 Good soaking & temperature control 』 ＆『 Not brought into direct contact between reaction liquid and refrigerant 』＆『 Robust system 』

Located in upper and lower /ultra-low temperature reaction tube
　　『 Can be dropped formulations in reaction liquid under the ultra low temperature 』

Selectively using the plurality of refrigerant
『 Reducing the manufacturing hours 』 ＆『 Energy reduction 』

Our facilities

Small	200L	SUS	located in upper and lower　：　1 system
	400L
Medium	1000L	SUS	located in upper and lower　：　1 system
	2000L
Large	4000L,6500L	SUS	located in upper and lower　：　2 systems
	5200L,5200L

■High temperature reactions

＜Manufacturing facility_example＞

Indirect heating system/oil
　　『 Good soaking & temperature control 』 ＆『 Not brought into direct contact between reaction liquid and heat medium 』 ＆『 Robust system 』

High temperature specification GL Reactor
　　『 Adaptable various reaction conditions 』

Separate heating system from cooling system
『 Reducing the manufacturing hours 』 ＆『 Energy reduction 』

Our facilities

Small	200L	GL	up to 230℃　heat medium
Medium	1000L	GL	up to 230℃　heat medium
	2000L
	3200L		up to 200℃　heat medium

■Hydrogenation reaction

Details
・Amount to use/per year　　　　　　 　　:　54,000㎥
・Catalyst　　　　　　　　　　　　　　　    :　Pd-C,Raney-Ni　 etc.
・Respond to vapor‐liquid reaction　　　　 :　Scaling up of gas transfer coefficient
・Safety measures　　　　　　　　　　　　:　Water leak detection method　＆　Dispose hydrogen gas

Our facilities

Small	200L	GL	１
Medium	1000L	SUS	２
	2000L
	2000L	GL	１
Large	4000L	GL	１
	5000L		１

Laboratories and other testing facilities.